Suppressed lipolysis in genetically fat pigs

Adipokinetic hormone-induced lipolysis in the fat

The pathway for the adipokinetic hormone-stiniulated synthesis of sn-1,2-diacylglyceroIs in the adult Manducu sexta fat body was studied. Adult fat body lipids were labeled by feeding 5th instar larvae either with [9,10(n)-3H]oleic acid or [ 1 (3)-3H]glycerol and after 32 days insects at the adult stage were used. This long-term prelabeling led to labeled fat body acylglycerols in which triacyl...

Fat Digestion: Intestinal Lipolysis and Product Absorption

Fat digestion in the breastfed newborn infant is a process catalyzed by three Upases. The process is initiated in stomach contents by gastric lipase and continues in the upper part of the small intestine by pancreatic colipase-dependent lipase and human milk bile-salt-stimulated lipase (BSSL). Development of powerful techniques in molecular biology has made it possible to gain better insight in...

Effects of body fat distribution on regional lipolysis in obesity.

UNLABELLED To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ([1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) age-matched premenopausal women in the overnight postabsorptive state. Splanchnic palm...

Genetically modified pigs for medicine and agriculture.

The ability to genetically modify pigs has enabled scientists to create pigs that are beneficial to humans in ways that were previously unimaginable. Improvements in the methods to make genetic modifications have opened up the possibilities of introducing transgenes, knock-outs and knock-ins with precision. The benefits to medicine include the production of pharmaceuticals, the provision of org...

Lipolysis meets inflammation: arachidonic acid mobilization from fat.